Abstract: Systems of progression of carcinogenetic pathways appear a largely acquired form of genetic evolutionary change bordering on such phenomena as hyperplasia and as manifested in dysplastic lesions. A central concept of specific cell of origin of tumors would be contrary to evolving dynamics of a stem cell population that circulates as systems of initial angiogenesis which, in turn, are subsequently established within tumor cell population confines. It is indeed in the spread of localized groups of endothelial cells as angiogenic sprouts that there would further develop a pattern of infiltrative tumor cell growth that subsequently involves lymphatic and blood dissemination of neoplastic cells. Metastases are an expression of a stem cell biology that promotes a self-amplification of systems of proliferation of tumor cells that interact with growth factors and angiogenesis in the creation of a tumor biologic milieu conducive to even further progression. There is a tendency for biologic progression in carcinogenesis that would predetermine and subsequently characterize tumor cell proliferative events as self-amplification systems of acquired genetic damage in neoplastic cells.