Abstract: Integral ischemic and inflammatory conditioning influences in determining responsiveness of cells and tissues in transforming pathology ranging from infection to neoplasia to tissue atrophy would in various ways perhaps help delineate pathways of pathologic progressiveness beyond simple etiologic considerations. Indeed, responsiveness of injured cells, tissues and organs as an inflammatory series of pathways in a conditioning setting induced by variable states of pre-existing or coincident ischemia might perhaps help account for the development of different patterns of pathologic progressiveness in cells and tissues. Indeed, a system of neoplastic transformation would be distinct from one of active infection, of progressive tissue atrophy, or of evolving frank infarction, simply in terms of the nature of the responsiveness pathways as developing in injured cells and tissues in the first instance. Ischemic effect would itself perhaps prove a prime mode of influence in determining the nature of such responsiveness of cells, tissues, and organs when injured in ultimately distinguishing between a pattern of active infection versus one of neoplasia or of atrophy in a progressive setting of disease evolution and transformation.