Abstract: Eighteen bacteria isolates from the Nigeria Currency belonging to five different species were selected for antibiotic susceptibility test using commercially available drugs. The antibiotics used are Tetracycline, Cetrimoxazole, Augumentin, Gentamicin, Amoxycillin, Ofloxacin and Nalidixic acid. The disc diffusion technique was employed and inhibition observed as clear zones around the antibiotics. Inhibition zones were measured using meter rule and measurement greater than 0.5 cm was regarded as susceptibility. Bacillus sp. was found to be resistant to all drugs except Ofloxacin. Proteus sp. was susceptible to all antibiotics except Nalidixic acid. Enterobacter sp. was found to be resistant to Amoxycillin, Cotrimoxazole, Augumentin and Tetracycline while it was susceptible to Gentamicin, Nalidixic acid and Ofloxacin. Citrobacter sp. was found to be resistant to Cotrimoxazole, Nalidixic acid and Tetracycline but susceptible to Amoxycillin, Gentamicin, Ofloxacin and Augumentin. Staphylococcus species was resistant to Amoxycillin, Cotrimoxazole, Nalidixic acid and Augumentin and Tetracycline but susceptible to Ofloxazole and Gentamicin. The general resistance was exhibited against the cheap, easily available and accessible antibiotics while susceptibility was to very expensive antibiotics, thus making the treatment of infections caused by money very expensive. The minimum inhibitory concentration of Ceftriazone on Enterobacter sp., Citrobacter sp. and Staphylococcus sp. are 0.5, 0.29 and 0.29 �g mL ¹ while for Gentamicin it was 0.3, 0.07 and 5 �g mL ¹ This reveals that infection or disease resulting from contaminated currency will be expensive to treat as common and affordable antibiotics may not be effective.