Authors : Fatemeh Babadi, Ali Asghar Hemmati and Ali Kordian
Abstract: Sialorrhea is a common clinical problem in children and adults that can have important social and medical consequences.The aim of this was to evaluate the effects of the sage extract in the salivary flowrate in rats. In this experimental study, 18 rats were divided into three equal groups: Group A: in this group a single dose of 10 mg kg–1 of the salvia officinalis extract was injected; Group B: in this group a single dose of 10 mg kg–1 of saline was injected and Group C: that rats received a single dose 10 mg kg–1 of atropine. Then, the amount of saliva after injection in four 7 min intervals was measured consecutively and results were analyzed with multiple t-test (p<0.05 was considered significant).The result showedafter injection of atropine salivation was significantlylower as compared to other groups. The most of the reduction was in time points of 14 and 21 min, respectively. In addition, the salivary flow rate did not decreased after injection of salvia officinalisextract in comparison with normal saline. The findings of this study demonstrated that salvia officinalis extractcannot cause asignificant reduction thesalivary flow rate in rat.
Fatemeh Babadi, Ali Asghar Hemmati and Ali Kordian, 2016. The Effects of Salvia officinalis Extract on Salivary Flow Rate in Rats. International Journal of Tropical Medicine, 11: 232-235.