Authors : Olalere Fatai Dayo, Blessing Chekwube Eluke, Ernest Okem Ukaejiofo, Olatubosun Luqman Olayinka, Chukwu Ikechukwu Johnpaul, Ogunwale Ayobami Kolawole Tajudeen, Ikegwuonu Ifeoma Chinwe, LawaL Sikiru Adetona, Nafiu Abdulrasak, Afolabi Onaolapo Olugbenga and Abioye Adesola Idowu Abdurraheem
Abstract: The study was done to investigate the haematopoietic and hepatoprotective modulatory effects of the leaf extract of Colocasia esculenta in Carbon tetrachloride (CCl4 ) induced hepatotoxic Wistar rats. About 30 albino Wistar rats were divided into six groups of six per group for the study. Group 1 served as the control group and received no treatment while group 2 was the negative control and was treated with 0.5 mg/kg CCl4 only. Group 3 served as the positive control and was treated with CCl4 and 100 mg/kg silymarin. Groups 4-6 were all induced with CCl4 and then administered with varying doses of the extract (100, 200 and 400 mg/kg, 4 respectively). Blood samples were collected from all rats after 14 days under ether anesthesia following international guidelines on the use and handling of animals and were subjected to laboratory analysis according to standard techniques. The result obtained revealed that the Aqueous leaf Extract of Colocasia esculenta (AECE) at varying doses further significantly decreased all estimated markers of liver function (Aspartate Transaminase (AST) Alanine Transaminase (ALT) and Alanine Phosphatase (ALP) after the administration of CCl4 . The extracts equally showed increased in platelet (thrombocytosis), however, total White Cell count (WBC), Haemoglobin (Hb), Red Cell count (RBC), Packed Cell Volume (PCV) and red cell indices were statistically significantly reduced (p<0.05). Tissue morphology was restored by the AECE at varying doses. The findings revealed that leaf extract of Colocasia esculenta possesses potent hepatoprotective properties enhanced thrombopoiesis and is a potential agent to correct hepatotoxicity premised on its efficacy, affordability, safety and availability following standardization/clinical trials.
Olalere Fatai Dayo, Blessing Chekwube Eluke, Ernest Okem Ukaejiofo, Olatubosun Luqman Olayinka, Chukwu Ikechukwu Johnpaul, Ogunwale Ayobami Kolawole Tajudeen, Ikegwuonu Ifeoma Chinwe, LawaL Sikiru Adetona, Nafiu Abdulrasak, Afolabi Onaolapo Olugbenga and Abioye Adesola Idowu Abdurraheem, 2017. Hepatoprotective and Haematopoietic Modulatory Efficacy of Leaf Extract of Colocasia esculenta in Albino Wistar Rats. International Journal of Tropical Medicine, 12: 35-41.