Authors : Salmah Ismail , Son Radu , Khalifah Sidek , Mohd Azhar Arifffin , Mohammad Nazmul Hasan Maziz , Irwan Hamzah and Mahmood Ameen Abdulla
Abstract: There are four groups of balb/c mice with each of it consists of 6 animals. Group 1, 2 and 3 were injected with dexamethasone daily for three days and experimentally infected with Pasteurella multocida, Escherichia coli harboring a recombinant plasmid ABA392 and Staphylococcus aureus respectively. Whereas, group four serve as control. At 24, 48 and 72 hours post-infection a marked increase in total leucocytes counts while differential leucocytes count revealed a marked increase in neutrophils and decrease in lymphocytes and monocytes in all dexamethasone-treated animals and was more predominant in group 1 and 2 post infection in all animals. At 72 hours post-infection, the histological examination reveals haemorrhagic (hemorrhagic septicaemia) features of lungs in dexamethasone-treated mice and infected with P. multocida and the recombinant plasmid ABA392 but not with the dexamethasone-treated and infected with S. aureus indicate that recombinant plasmid ABA392 may harbor a sequence that may code for virulent factor of Pasteurella multocida.
Salmah Ismail , Son Radu , Khalifah Sidek , Mohd Azhar Arifffin , Mohammad Nazmul Hasan Maziz , Irwan Hamzah and Mahmood Ameen Abdulla , 2003. Effect of Dexamethasone Treatment on the Hematological and Histological Parameters of Mice Following Experimental Bacterial Infection. Journal of Animal and Veterinary Advances, 2: 231-236.