Authors : E.K Bawa , V.O. Sekoni , D. Ogwu , K.A.N. Esievo and D.V. Uza
Abstract: The results of chemotherapy with the Trypanocidal drug Novidium, on the clinical manifestation ? of Trypanosoma vivax infected pregnant Yankasa (YK) and pregnant West African Dwarf (WAD) ewes was investigated. Three groups of pregnant YK and pregnant WAD ewes, comprising of 6 YK and 6WAD per group, were randomLy assigned to first, second and third trimesters of pregnancy and infected with T. vivax at each trimester. A fourth group comprising of 3 uninfected pregnant YK and 3 uninfected pregnant WAD ewes were the controls for the study. Two weeks post infection the infected ewes in each trimester period were divided into two equal groups of three ewes each. One group was treated with Novidium (Homidium chloride), ? at 1.0 mg kgG body weight, the other group remained untreated. Blood samples from the treated ewes were 1 negative for trypanosomes within 4 days post-chemotherapy. As the study progressed, clinical signs associated with trypanosomosis, such as anaemia indicated by low packed cell volume (PCV), loss in body weights, pyrexia and decline in total plasma protein (TP) values observed in the infected ewes, disappeared gradually following chemotherapy. Treatment had significant (p#0.05) positive effects on PCV values of the treated YK and WAD ewes in the third trimester, TP values of treated YK in the first and second trimester, body weight of treated YK ewes in the second trimester, TP values of treated WAD ewes in the first, second and third trimester and body weights of treated WAD ewes in the second and third trimesters. The trimester of pregnancy and breed of ewe influenced the results of Novidium chemotherapy on observed clinical parameters.?
E.K Bawa , V.O. Sekoni , D. Ogwu , K.A.N. Esievo and D.V. Uza , 2005. Results of Novidium (Homidium Chloride) Chemotherapy on Clinical Manifestation of ? Trypanosoma vivax Infected Pregnant Yankasa and West African Dwarf [Wad] Ewes . Journal of Animal and Veterinary Advances, 4: 637-641.