Authors : M. SH. Rhaymah
Abstract: The effects of aqueous fruit extracts of Melia azedarach (Meliaceae) and Cotoneaster prostratae (Rosaceae) on rat complements were examined. Both extracts showed significant anticomplementary activities on rat serum in both classical and alternative pathways. The effect was more pronounced in classical than alternative pathway. The IC 50% obtained for M. azedarach and C. prostratae in the alternative pathway was 31.2 and 1.9 mg mL 1, respectively, whereas IC 50% recorded in the classical pathway was 7.8 mg mL 1 for M. azedarach and 0.9 mg mL 1 for the C. prostratae. Although both extracts were capable of inhibiting complement activity, total inhibition was achieved at higher M. azedarach extract concentrations when compared with those of C. prostratae extract.
M. SH. Rhaymah , 2006. Anticomplementary Activities of Aqueous Extracts of the Fruits of Melia azedarach and Cotoneaster prostratae in Rats. Journal of Animal and Veterinary Advances, 5: 197-199.