Abstract: Many rural people world-wide depend on traditional methods of treatment of livestock diseases. In the Karamoja region of Uganda, the pastoralists have accumulated a vast amount of knowledge on natural products and traditional livestock management systems. But little work has been done to evaluate and establish a pharmacological basis for their use. In this study, some of the plants that are used by the Karimojong pastoralists were evaluated for ascaricidal activity in vitro. Among the plant extracts evaluated in the study Athroisma sp., Sarcocephalus latifolius, Pseudocedrela kotschyi had significant ascaricidal activity. But there was variation in the efficacy of the plant extracts. Athroisma sp., Pseudocedrela kotschyi and Sarcocephalus latifolius all achieved 100% activity against Ascaris suum. Athroisma sp. achieved 100% activity against the Ascaris at concentrations of 2 , 4 and 8 mg mL^-1. 100% activity was achieved after 36 h of incubation for the 8 mg mL^-1 concentration and after 48 h of incubation for the 2 and 4 mg mL^-1 concentrations. Pseudocedrela kotschyi achieved 100% mortality at concentrations of 4 and 8 mg mL^-1. 100% mortality was achieved after 36 h of incubation and after 48 h of incubation of the Ascaris for the 4 and 8 mg mL^-1 concentrations, respectively. Athroisma sp. Sarcocephalus latifolius. Two of the plants (Pseudocedrela kotschyi and Terminalia brownie) with the highest activity may therefore have some potential for the treatment of nematode infections in ruminants.