Authors : Farnood Shokouhi Sabet Jalali , Siamak Saifzadeh , Amir Abbas Farshid , Hossien Tajik , Reza Bagheri and Rahim Mohhammadi
Abstract: The aim of this study was to examine the effectiveness of topical administration of Iranian honey in acceleration of healing of linea alba and prevention or reduction of post-surgical peritoneal adhesions in dog. The study was conducted with 20 adult dogs with mean weight of 20±2.42 Kg. The animals were selected randomly and divided into two equal groups. Laparotomy was performed routinely on all animals through a caudal midline abdominal incision of 10 cm length. Control group received saline treatment and in experiment group the lesions were treated with honey. The abdominal incision was then closed with continuous pattern of 0 polyglactine 910 (vicryl) suture. Three weeks after laparotomy, the dogs were sacrificed and the adhesions were graded according to their degree of severity based on Evans`s scoring system. Overall, 60% (n = 6) of the control animals and 20% (n = 2) of the experiment animals presented with moderate (grade 2) and severe (grade 3) adhesions. In the experiment group, there were 8 (80%) dogs with grade-0 or grade-1 adhesions but in the control group there were 4 (40%) dogs with the same grades of adhesions. The difference between two groups was shown to be significant (p<0.05). Histological analysis revealed that honey did not induce a specific inflammatory reaction and caused a fibrotic response compared with the untreated group. Inflammatory reactions were seen as disseminated foci of inflammatory cells in control group. Based on the results of this study, it was concluded that honey appears to be a useful treatment for acceleration healing of linae alba and had high effectiveness in reducing post-operative adhesions.
Farnood Shokouhi Sabet Jalali , Siamak Saifzadeh , Amir Abbas Farshid , Hossien Tajik , Reza Bagheri and Rahim Mohhammadi , 2007. Efficiency Assessment of Iranian Honey on Healing of Linea Alba Following Exploratory Laparotomy in Animal Model. Journal of Animal and Veterinary Advances, 6: 238-241.