Abstract: Retrospective data concerning the occurrence of pregnancy toxemia in ewes presented to Veterinary Teaching Hospital, King Faisal University from 1992-2003 was obtained. Twenty seven ewes presented to same clinic in 2004 with the suspicious of pregnancy toxemia were subjected to clinical and laboratory examinations. Blood samples for glucose level determination were taken from the 6 ewes proved to have pregnancy toxemia. At the same time blood samples were collected from 6 healthy non pregnant and 6 healthy pregnant ewes as control. The incidence of pregnancy toxemia in the 12 years recorded ranges between 6.5-37%. The highest incidence was reported in 1998 (37%), while the lowest incidence was reported in 2003 (6.5%). The clinical manifestations showed by the 6 animals proved to have disease were mainly nervous manifestations. The level of blood glucose in ewes with pregnancy toxemia was 1.02�0.14 mmol L ¹, while in healthy non pregnant and pregnant was 2.95�0.65 mmol L ¹ and 2.7�0.14 mmol L ¹, respectively. It could be concluded that the incidence of the disease in reported years is low to moderate and the disease has significant effect of blood glucose level.