Authors : F.C. Iheukwumere , E.C. Ndubisi and A.H. Abu
Abstract: Three groups of 6 healthy mature Yankasa rams, aged 1.5-2.5 years weighing between 30 and 50 kg were assigned to either 12.25 mg (CDI) or 24.5 mg (CD2) clomiphene citrate as ClomidR) (Bruno Pharmaceutici S p A, Rome) daily for 5 days. Another group of 6 rams was given normal saline during the same period to serve as control (CON). All treatments were given to study the effect of the drug on daily sperm production, gonadal and extragonadal sperm reserves. All the solutions were given as oral douches. The results indicate daily sperm production (109) for the control (CON) 2.15�0.64 differed significantly (p<0.05) from (CDI) 5.16�0.12 and (CD 2) 4.85�0.16. Daily sperm production/gram/testis (109) were similar between treatments. Gonadal sperm reserves (109) for (CD1) 17.45�1.64 differed significantly (p<0.05) from (CD2) 14.25�1.45 and (CON) 12.15�1.15. Mean caput sperm reserves (108) for (CD1) 4.10�0.06 differed significantly (p<0.05) from (CD2) 3.64�0.04 and (CON) 2.25�0.03. Mean corpus sperm reserve (108) for (CD1) 5.10�0.08 differed significantly (p<0.05) from (CD2) 4.65�0.05 and (CON) 3.25�0.06. Mean caudal sperm reserve (108) for (CD1) 6.25�0.54 was similar (p>0.05) to (CD2) 5.48�0.62 but they differed significantly (p<0.05) from (CON) 4.15�0.21. Ductus deferens sperm reserve was similar (p>0.05) between treatment groups. High correlations were found between testis weight and daily sperm production and testicular sperm reserves. The gonadal and extragonadal reserves and daily sperm production values obtained in this study are within the range reported for exotic breeds.
F.C. Iheukwumere , E.C. Ndubisi and A.H. Abu , 2008. Effect of Clomiphene Citrate (Clomid®) Fertility Drug on Sperm Production Rate Gonadal and Extragonadal Sperm Reserves of Nigerian Yankasa Rams. Journal of Animal and Veterinary Advances, 7: 633-637.