Authors : Shozo Tomonaga, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu and Mitsuhiro Furuse
Abstract: We previously reported that Chicken Breast Extract (CBEX) had an antidepressant-like effect in rats. In the present study to further clarify, the mechanism of action of CBEX, the effects of CBEX on the brain serotonin (5-HT) system was investigated in the ventral hippocampus of rats, using an in vivo micro dialysis. 5-Hydroxyindoleacetic acid, a major metabolite of serotonin, was significantly increased in animals orally administered CBEX. This result indicates that CBEX may activate 5-HT metabolism in the brain. Since, a previous study indicated that orally administered CBEX increases levels of the putative neurotransmitter carnosine in the hippocampus, carnosine might be involved in the action of CBEX.
Shozo Tomonaga, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu and Mitsuhiro Furuse, 2009. Oral Administration of Chicken Breast Extract Activates Serotonin Metabolism in the Hippocampus of Rats. Journal of Animal and Veterinary Advances, 8: 2276-2279.