Authors : Hossien Tajik , Farnood Shokouhi Sabet Jalali , Sharam Javadi , Yasser Shahbazi and Masoumeh Amini
Abstract: There are not any reports in related to evaluation of the efficacy of a combination of natural honey and medicinal plants in the therapeutic usages. The aim of this study was performed to evaluate the accelerating effect of a combination of honey and aqueous extract of yarrow on the burn wound healing in rabbit. Twenty adult white rabbits, with mean weight of 1900±220 g were studied. Burn wounds (20x25 mm2) were created in dorsal region of each animal, according to Hoekstra model. The experiment wounds were included: In A group, wounds were treated with 5 mL of natural honey every day for 21 days. In B group, wounds were treated with 5 mL of aqueous extracts of yarrow every day for same time. In C group, wounds were treated with 5 mL of a combination of honey-aqueous extracts of yarrow (50-50%) every day for same time. The control wounds were only washed with the same amount of normal saline. Clinical and microbiological examinations of the burn wounds were carried out on 0, 7, 14 and 21days of the experiment. The wounds were photographed and compared for rate of wound contraction with digital scanning software. Base on the results of this study, significant differences were seen between the experiment (A, B and C) and control groups for the rate of contractions (p<0.05). Moreover, experimental wounds have lesser total bacterial count in compared to the control wounds on the day 21 (p<0.05). But in the experimental groups, there are not significant differences between sub-groups (A, B and C) and the combination of honey-yarrow has not any benefit than two other sub-groups (A, B) from clinical and microbiological aspects. In spite of these results, honey and yarrow still can be separately considered as low cost, easily available and potent topical agents for treatment of burn wounds.
Hossien Tajik , Farnood Shokouhi Sabet Jalali , Sharam Javadi , Yasser Shahbazi and Masoumeh Amini , 2009. Clinical and Microbiological Evaluations of Efficacy of Combination of Natural Honey and Yarrow on Repair Process of Experimental Burn Wound. Journal of Animal and Veterinary Advances, 8: 907-911.