Abstract: The aim of the present study was to compare the hepatic Triacyiglycerols (TAG) and serum Non-esterified Fatty Acids (NEFA) and serum vit. E and selenium in cows in different stages of productivity slaughtered at Tabriz abattoir. So, a total of 204 blood and liver samples were collected from the indigenous hybrid cows immediately after being slaughtered at the abattoir. The cows were divided into 4 groups according to their pregnancy statuses: 1-8 months pregnant, 8-9 months pregnant, less and more than 1 month of partunition. Percentage of TAG were measured in the liver and NEFA, vit. E and selenium were measured in the blood circulation. All the liver samples, in this study, show some degrees of fatty infiltration. The accumulation of that in the liver rose significantly (p<0.001) during the 1st month after parturition and returned to the same level of pregnancy after 1 month. We also noticed that serum NEFA concentration was significantly higher (p<0.001) during the 1st month of parturition and serum vit. E and selenium level was significantly lower (p<0.001) in newly calved group (<1 month after parturition). These results reveal that fatty liver is quite common in all the animals in the region especially in their early lactation. These findings indicate the necessity of reconsideration in the animal’s food policies in the area and some especial approaches during the early phase of lactation.