Abstract: To investigate the influence of selenium on hepatic antioxidant capacity in ducklings administrated with Afatoxin B1 (AFB1), ninety 7 days old ducklings were randomly divided into three groups (groups I-III). Group I was used as a blank control. Group II was administered with AFB1 (0.1 mg kg-1 body weight). Group III was administered with AFB1 (0.1 mg kg-1 body weight) plus selenium (sodium selenite, 1 mg kg-1 body weight). All treatments were given once daily for 21 days. The results showed that the activity of hepatic Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-Px) and Glutathione Reductase (GR) in group II ducklings significantly decreased when compared with group I (p<0.01). Furthermore, the content of hepatic Malondialdehyde (MDA) significantly increased (p<0.01). However, the activities of hepatic SOD, CAT, GSH-Px and GR in group III ducklings significantly increased when compared with group II (p<0.05). In addition, the content of hepatic MDA significantly decreased (p<0.01). These results revealed that AFB1 significantly induced hepatic antioxidant function dysfunction. However, selenium could significantly alleviat the negative effect induced by AFB1.
D.Y. Shi, S.Q. Liao, R.S. Su, R.Q. Lin, Y.C. Lin, Z.X. Tang and S.N. Guo, 2012. Influence of Selenium on Hepatic Antioxidant Capacity in Ducklings Intoxicated with Afatoxin B1. Journal of Animal and Veterinary Advances, 11: 1052-1055.