Authors : Bin Tong, Youji Muramatsu, Takuji Yamamoto, Hideki Tanomura, Takeshi Ohta, Hiroyuki Kose, Toshie Sugiyama and Takahisa Yamada
Abstract: Researchers have previously showed that the septin 7 (CDC10) gene involved in cellular proliferation possesses expression differences in musculus longissimus muscle between low-marbled Holstein and high-marbled Japanese Black steer groups. In the present study, researchers found that a marker (BM6437) close to the CDC10 was polymorphic between low-marbled Holstein and high-marbled Japanese Black steer groups and exhibited significantly different allelic distribution between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. Further, researchers detected Single Nucleotide Polymorphism (SNP) in the promoter region of the CDC10 gene between low-marbled Holstein and high-marbled Japanese Black steer groups. The allelic distribution of the SNP, referred to as g.63629097G>C in the CDC10 was indistinguishable between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. The findings suggest that an unidentified true causal mutation which is in linkage disequilibrium with the BM6437 marker but not the g.63629097G>C SNP may be related to changes in CDC10 gene expression and/or marbling.
Bin Tong, Youji Muramatsu, Takuji Yamamoto, Hideki Tanomura, Takeshi Ohta, Hiroyuki Kose, Toshie Sugiyama and Takahisa Yamada, 2012. Polymorphism in Promoter Region of CDC10 Gene Showing Marbling-Associated Expression Changes. Journal of Animal and Veterinary Advances, 11: 1930-1933.