Abstract: The effects of ephedrine on Arterial Blood Pressure (ABP), heart rate, respiratory rate and some haematology and biochemistry parameters were carried out on six camels in two periods. In the first period, all camels received Intravenous (IV) 0.2 mg kg^-1 xylazine while in the second period, same camels received IV 0.2 mg kg^-1 ephedrine followed 10 min later by IV 0.2 mg kg^-1 ephedrine and 0.2 mg kg^-1 xylazine administered at same time. Cardiopulmonary measurements were taken at baseline and were further recorded at 10, 20, 30, 40, 50 and 60 min after treatment in both groups. Mean heart rate, respiratory rate and ABP measurements decreased significantly after xylazine in the first period. Mean heart rate in the second period decreased significantly at all times compared to baseline and to first period while mean ABP measurements were significantly higher at 10, 20, 30 and 40 min compared to first period. There was a significant decrease of Platelet count (PLT), Haemoglobin (HB), Urea Nitrogen (BUN), Albumen (ALB), Alanine aminotransferase (ALT) and Glucose (GLU) in the first period compared to the second period and there was significant increase of Calcium (Ca) and potassium (K⁺) after treatments in the second period. Ephedrine was safe and effective in improving ABP in xylazine induced hypotension in camels.