Abstract: Interleukin-17 is a critical pro-inflammatory cytokine in the development of autoimmunity and the immune responses against infection of bacteria, fungus and parasites. In the present study, dynamics of IL-17 and cytokines associated with IL-17 producing in serum and milk in experimental mastitis challenged with S. aureus and E. coli in dairy goats were monitored using commercial ELISA kits. The results showed that the levels of IL-17 in milk were peaked at 24 or 48 h post challenged with E. coli or S. aureus, respectively but no detectable peak was found in serum. The levels of TGF-β, IL-6 and IL-1β in milk were elevated in goats challenged with E. coli or S. aureus but only slight fluctuant were found in serum. These indicated that IL-17 was an important cytokine in the inflammation development of dairy goat mastitis challenged with E. coli or S. aureus and the local pro-inflammatory cytokines milieu plays an important role in the development of subclinical mastitis whether infected with E. coli or S. aureus.
X.Q. Jing, Y.Q. Zhao, C.C. Shang, Y.L. Yao, T.T. Tian, J. Li and D.K. Chen, 2012. Dynamics of Cytokines Associated with IL-17 Producing Cells in Serum and Milk in Mastitis of Experimental Challenging with Staphylococcus aureus and Escherichia coli in Dairy Goats. Journal of Animal and Veterinary Advances, 11: 475-479.