Abstract: Animal experimental models are widely used in medical sciences in general and particularly in dentistry. The reasons for using animal models in dentistry are varied and included satisfying study hypothesis, understanding of progression of pathogenesis of certain diseases including periodontitis. Animal models are also used for other scientific aspects such as testing new medicines prior to their applications in clinical practice. The main challenge is how to select the appropriate animal experimental model. In this review, we reviewed various proposed models to be used in dentistry. Which models to be used and when to be used and what are the conditions that determine the right selection were discussed. Taken together, the use of animal models in dentistry is crucial to establish new findings, prove hypothesis of the study. There are many animal models that have been proposed to be used in dental experiments. Actually, there is no unique animal model for all disease and accordingly, animal model has to be carefully selected.