Authors : Yao Wu, Bin Tong, Kaifeng Wu, Seiki Sasaki, Youji Muramatsu, Takeshi Ohta, Hiroyuki Kose, Takahisa Yamada, Dong Zhang and Guoxin Ni
Abstract: Growth performance as well as marbling is the main breeding objectives in Japanese Black cattle, the major beef breed in Japan. The Insulin Receptor Substrate 1 (IRS1) gene is reported to be associated with insulin resistance and birth weight in human and has been previously shown to be located within genomic region of a quantitative trait locus for growth-related trait. The previous study detected a Single Nucleotide Polymorphism (SNP), referred to as g.120947716T>C in the promoter region of the IRS1 gene which exhibited significantly different allelic distribution between Japanese Black sires with extremely high predicted breeding value and the sires with extremely low one for Carcass Weight (CWT) and Rib Thickness (RT) in a preliminary study. In this study, researchers analyzed the effect of the IRS1 g.120947716T>CSNP genotypes on the growth-related carcass trait in Japanese Black beef cattle. The SNP was associated with CWT and RT (p = 0.030 and 0.005, respectively) in experiment using 100 Japanese Black sires. This finding suggests possible effect of the g.120947716T>C on the growth-related trait in Japanese Black beef cattle. The IRS1 SNP may be useful for effective marker-assisted selection to increase the beef productivity in Japanese Black beef cattle.
Yao Wu, Bin Tong, Kaifeng Wu, Seiki Sasaki, Youji Muramatsu, Takeshi Ohta, Hiroyuki Kose, Takahisa Yamada, Dong Zhang and Guoxin Ni, 2014. Association of Single Nucleotide Polymorphism in IRS1 Gene with Growth-Related Trait in Japanese Black Beef Cattle. Journal of Animal and Veterinary Advances, 13: 37-40.