Authors : Qinghua Chen, Zenghui Ding, Wei Qiu and Jian-Hua He
Abstract: This study was conducted to investigate the effect of Achyranthes Bidentata Polysaccharide (ABP) on growth performance, inflammatory responses and hormones in weaned piglets after Escherichia coli Lipopolysaccharide (LPS) challenges. A total of 48 crossbred (Duroc x Large; White x Landrace) male pigs weaned at 28 days of age (8.45±0.14 kg) were randomly allotted to one of four treatments by initial BW in a 2x2 factorial design that included a dietary addition of ABP (0 or 500 mg kg-1) and immunological challenge (with LPS or saline). On day 14 and 21, pigs were injected intraperitoneally with either 100 μg kg-1 BW of LPS or an equivalent amount of sterile saline. Blood samples were obtained 3 h after injection for analysis of Tumor Necrosis Factor-α (TNF-α), Prostaglandin E2 (PGE2), cortisol, Growth Hormone (GH) and Insulin-like Growth Factor (IGF)-I. The results showed that LPS challenge decreased Average Daily Feed Intake (ADFI) (p<0.05) from 14∼21 and day 21∼28. ABP increased ADG (p<0.05) and ADFI (p<0.05) from day 21∼28. An interaction (p<0.05) between LPS challenge and diet was observed for the plasma concentration of TNF-α, PGE2, cortisol, and IGF-I after both LPS challenges such that among LPS-treated pigs, pigs fed the ABP diet were lower for TNF-α (p<0.05) and higher IGF-I (p<0.05) than those receiving the control diet. These results indicated that ABP alters the release of inflammatory cytokines that may lead to improved pig performance during an immunological stress.
Qinghua Chen, Zenghui Ding, Wei Qiu and Jian-Hua He, 2014. Achyranthes bidentata Polysaccharide Decreases Inflammatory Cytokine Secretion in Weaned Piglets after LPS Challenge. Journal of Animal and Veterinary Advances, 13: 454-459.