Authors : Ozcan Budak, Ender Yalcinkaya, Eray Caliskan, Begum Alyuruk and Sureyya Ceylan
Abstract: Type 1 diabetes was shown to affect oocyte quality and subsequent embryo development. In this study, we aimed to evaluate the effect of diabetes on oocyte quality based on morphological criteria and subsequent embryo development in a mouse model. Female CD 1 mice were used as the experimental animals for superovulation and male mice were used as the source of spermatozoa for IVF. Significant differences were observed in the morphological criteria such as perivitelline space, zona pellucida and polar bodies between both groups (p<0.05). Following superovulation and IVF, embryo quality and blastocyst development rate were compared between groups and it was observed that embryo quality and blastocyst development rate were superior in control group compared to diabetic one (p<0.05). These results suggest that even chemically-induced diabetes may show adverse effects on female reproductive cells and subsequent embryo development.
Ozcan Budak, Ender Yalcinkaya, Eray Caliskan, Begum Alyuruk and Sureyya Ceylan, 2015. Evaluation of the Effect of STZ-Induced Diabetes on Oocyte Morphology and Subsequent Embryo Development in Superovulated Mice. Journal of Animal and Veterinary Advances, 14: 345-350.