Authors : Kimiyoshi Okano, Taro Kimura and Kazuya Edamura
Abstract: The dose-dependent isoflurane-sparing effect of maropitant in dogs undergoing Ovariohysterectomy (OHE) was investigated. Thirty six female dogs undergoing OHE were randomly divided into 3 groups. The MAR-1 group dogs were premedicated with 1 mg kg-1 maropitant and 0.5 mg kg-1 morphine (n = 12). The MAR-5 group dogs were premedicated with 5 mg kg-1 maropitant and 0.5 mg kg-1 morphine (n = 12). The MOR group dogs received saline and 0.5 mg kg-1 morphine (n = 12). The intraoperative isoflurane-sparing effect was compared among the groups. The mean intraoperative isoflurane requirements during the surgery were 1.88±0.10, 1.76±0.13 and 1.69±0.16% in the MOR, MAR-1 and MAR-5 groups, respectively. The requirements of the MAR-1 and MAR-5 groups were significantly lower than that of the MOR group. The mean intraoperative isoflurane requirement during the surgery of the MAR-5 group was the lowest of all 3 groups. The isoflurane requirement at 40 min after the start of surgery of the MAR-5 group was significantly lower than that of the MAR-1 group. Preoperative administration of maropitant effectively reduces the intraoperative isoflurane requirement in a dose-dependent manner.
Kimiyoshi Okano, Taro Kimura and Kazuya Edamura, 2015. Dose-Dependent Isoflurane-Sparing Effect of Maropitant in Dogs Undergoing Ovariohysterectomy. Journal of Animal and Veterinary Advances, 14: 95-99.