Authors : Kimiyoshi Okano, Taro Kimura, Ryouichi Suzuki and Kazuya Edamura
Abstract: Maropitant exerts antiemetic effects and is also effective in reducing the inhalational anesthetic requirement. In this study, 20 Japanese domestic cats that were brought to a private animal hospital to be spayed were divided into two groups: one group was administered a combination of Maropitant and Buprenorphine (MAR group, n = 10) and the other group was administered saline solution and buprenorphine (control group, n = 10). In all cases, ovariohysterectomy was performed under general anesthesia using isoflurane. The isoflurane concentration was measured in both groups at the following stages: at 15 min after initiating inhalational anesthesia (T0 ), during skin incision (T1 ), left ovary retraction stimulation (T2), right ovary retraction stimulation (T3), uterus retraction stimulation (T4), start of abdominal closure (T5) and start of skin suture (T6). The isoflurane requirements in the MAR group were significantly lower than those in the control group at T4 -T6 (p<0.05) and the requirement decreased at T6 by approximately 5.5%. These results suggest that maropitant might have an isoflurane-sparing effect in cats undergoing ovariohysterectomy.
Kimiyoshi Okano, Taro Kimura, Ryouichi Suzuki and Kazuya Edamura, 2018. Isoflurane-Sparing Effect of Maropitant in Cats Undergoing Ovariohysterectomy. Journal of Animal and Veterinary Advances, 17: 82-86.