Abstract: The abilities to survive and job opportunities for graduates of higher education are now very limited because of the transformation of workers who replaced by many machines and information technology. This study aims to explore and describe the student’s personality in the implementation of science and technology for entrepreneurship with a production-based learning approach to higher education. The personality of the students is very determining the direction of success in the future, especially how students think and manage reviews their mindset. Implementation of entrepreneurship education and training in higher education, gradually changing the student’s mindset from graduation for seeking work turned into graduation for creating jobs. In entrepreneurship, learning is not only a given theory but also there are skills and practices of entrepreneurship through the approach of the production-based learning in higher education. Method of research used was descriptive quantitative and field observation in depth to 46 students. The personality of the students who are associated with the entrepreneurial character is analyzed from ten aspects roommates are divided into three playing parts, including, communication skills (speaking skills, speaking qualities, speaking content, sense of humor), added value (reliable have been more potential) and teamwork with others (willing to go together). Based on the results of the descriptive statistical analysis with SPSS 17.0, it shows that the personality condition of students in the implementation of science and technology for entrepreneurship with the production-based learning approaches in higher education ware very good. Therefore, it concludes that the personality of students who have the character of entrepreneurship in the development of education and entrepreneurship training in higher education is needed, so, it is expected that the graduates of higher education are able to create jobs.