Abstract: Seven live-in houses situated in two different types of housing conditions in Port Harcourt, Rivers State of Nigeria and their occupants were used in identifying the common mould related health problems associated with people living in houses with moisture problem. Five of the houses were identified with having moisture problem as a result of constant flooding from rainfall, poor or total lack of drainages and leakages from roofs, sinks, pipes and walls while the other two houses were basically moisture problem free. Air samples from all the rooms of the study sites were collected, processed and the presence of moulds confirmed in them. Eighty human specimens made up of hair, skin scrapes, nails and sputum from the occupants were processed with 20% KOH in a wet mount preparation and cultured on sabouraud dextrose agar incorporated with chloramphenicol. The percentage occurrence of mould related health problems encountered in this study were Tinea cruris (10%), Tinea capitis (20%), Tinea corporis (20%), Tinea unguium (15%), Tinea pedis (10%), Tinea barbae (5%) and persistent sneezing, headache and cough (20%). Tinea capitis, corporis and persistent sneezing headache and cough which accounted for 20% each were found to be the most common mould related health problems associated with people living in houses with moisture problem.