Authors : H.A. EL-Banna , A.H. Zaghlol and Rehab Madi
Abstract: Efficacy and tissue residue depletion and withdrwal period of water soluble formulation of florfenicol was studed in control healty and experimently E. coli infected broiler chickens. Florfenicol given orally in drinking water with atherapeutic dose (30 mg kg 1 body weight, twice daily) for 5 cosequetive ds. Florfenicol administration for 5 successive ds 30 mg kg 1 twice daily was highly efficacious in the control of the disease induced by E. coli. These finding indicated by the decreasing of mortality %, pm lesions and bacterial reisolation from birds treated with 30 mg kg 1 b wt twice daily for 5 ds as compared with group treated with 20 mg kg 1 b wt twice daily for 5 d. Florfenicol residue depletion from tissues of healthy chickens was faster than from tissues of infected ones. Oral administration of florfenicol twice daily for 5 consecutive ds in E. coli infected chickens resulted in a higher tissues concentration of the drug at different time interval after stopping the drug medication as compared with values recorded in healthy birds. Bile had the highest concentration of florfenicol followed by liver and kidney, while the lowest concentration was determined in fat and brain in both healthy and infected birds. Florfenicol was still detected in serum, bile and all tested tissues on the 6th d after discontinuation of medication in both healthy and infected birds, while all tissues of slaughtered healthy and infected birds could be considered drug free except liver of infected birds which had a concentration of 0.11�0.01 ug g 1 at 7th d after stopping of drug administration. A withdrwal period >6 ds in healthy chickens and >7 ds in infected ones is satisfactory.
H.A. EL-Banna , A.H. Zaghlol and Rehab Madi , 2007. Efficacy and Tissue Reside Depletion of Florfenicol (Water Soluble Formulation) in Healthy and E. coli Infected Broiler Chickens . Research Journal of Biological Sciences, 2: 319-325.