Authors : Mohammad Reza Jalali Nadoushan , Elham Neisani and Mitra Karbassi
Abstract: Breast cancer is the most common cancers in women in the world. Molecular markers are one of the most important prognosis factors. In this study, correlation of proliferative factor, Ki67, has been evaluated by grade, stage and axillary involvement in primary breast cancer. This study has been done by cross-sectional study on 69 paraffin blocks of patients with breast cancer which obtained from pathology department of shahid Mostafa Khomeini hospital, since 2000-2004. From each, two samples with 3 micrometer thickness were provided. One from tumor and one from lymphnode(s) which were stained by hematoxillin and eosin. Then we determined number of lymphnode(s) and grade according to Nattingham Modification of Bloom-Richardson criteria. Another section for Ki67 was evaluated by immunohistochemical staining. The results have been analyzed statistically according to grading, lymphnode(s) involvement and ki67-positivity. Our study showed that 100% of samples of ki67 were positive. The most samples were grade III, 43.5% and the least were grade I, 17.4%. 69.6% of the patients had axillary lymphnode(s) involvement. In this study, there was correlation between ki67 and axillary lymphnode(s) involvement. The expression of ki67 in patients with breast cancer should be noticed. It has to be paid attention to this marker as effective factor in prognosis of breast cancer in Iran. It can`t be concluded definitely by this study in its role in prognosis and it needs more study with more samples and longer following up.
Mohammad Reza Jalali Nadoushan , Elham Neisani and Mitra Karbassi , 2007. Correlation of Ki67-Positivity in Tumoral Cells` Percentage with Effective Factors on Prognosis in Primary Breast Cancer. Research Journal of Biological Sciences, 2: 326-328.