Abstract: Intraocular Pressure (IOP) may increase during general anesthesia due to intubation. Increasing of IOP in some surgical procedures may lead to complications and it is important to reduce IOP. The changes of the IOP and haemodynamic variable are evaluated during intubation and extubation at the end of general anesthesia. In this study, 51 patients were selected for orthopedic and general surgery. A standard general anaesthesia was treated to all of the patients. For maintaining airway during anesthesia, the patients were received directly laryngoscopy intubing technique. Intraocular pressure was measured at different stages prior to intubation and extubation and then at 1, 5 and 10 min after intubation and extubation with shiutze tonometer by a trained and expert person. The Blood Pressure (BP) and Heart Rate (HR) were measured. Results show that tracheal intubation and extubation cause increase in IOP at 1, 5 min after intubation. The highest increase in IOP level occurs one minute after extubation (43.41%). It was not significantly between increasing in IOP during above mentioned extubaion period. Intubation and extubation caused increase BP and heart rate. The highest increase in BP and heart rate happens at the first minute after intubation (30.63, 14.86%). It statistically was difference between increasing in the BP and HR during intubation and extubation (p< 0.05). Although IOP level was significantly increased but it was normal range. With the regards to increase in IOP level during extubation compare to intubation at prior and 1 min after intubation, it is recommended that the more accurate planning to prevent increasing of above-mentioned changes at the time of intubation.