Authors : Nazik Elmalaika Obaid Seid Ahmed Husain, Azza Salah Abdul Rahman Salih, Hind ElRayah Osman Musa and Ahmed Omer Elmubarak
Abstract: HPV was detected in cervical and oral cancers however to the best of the knowledge, there is no study covering its presence in Upper Respiratory and Digestive Tracts Squamous Cell Carcinomas (UR and DT SCCs) in Sudan. This study aimed at finding out the relation (if any) between HPV type 16 and UR and DT SCCs in Sudanese patients and to study the histopathology of these tumors. It is a descriptive, cross-sectional study in which ninety five formalin-fixed paraffin embedded tissues of UR and DT SCCs were used for DNA extraction (Real Genomics, Genomic DNA extraction kit [Mini] (Tissue), Real Biotech Corporation (RBC), Taiwan) and conventional polymerase chain reaction to detect the presence of HPV type 16 in those tissues. Statistics Package of Social Sciences was used for data analysis. Person Chi-square test for statistical significance with the 95% confidence level was used. Out of 95 patients with UR and DT SCCs there were 47 (49.5%) males. HPV DNA type 16 was detected in 10.53% of cases. The relation between the site of UR and DT SCCs and the gender as well as the site and the degree of differentiation was found to be statistically significant (p:0.035 and 0.009, respectively), however there was no significant relation between those sites and the age categories that were studied (p:0.097). Researchers concluded that HPV type 16 is unlikely to be a causative agent in UR and DT SCCs, however further studies are needed to support that and look for other viral types as a possible cause for these tumors.
Nazik Elmalaika Obaid Seid Ahmed Husain, Azza Salah Abdul Rahman Salih, Hind ElRayah Osman Musa and Ahmed Omer Elmubarak, 2012. Human Papillomavirus Type 16 in Sudanese Patients with Upper Respiratory and Digestive Tract Squamous Cell Carcinoma. Research Journal of Biological Sciences, 7: 83-86.