Abstract: After the third molar, congenitally missing of second premolars has the highest incidence. Endodontic treatment of second primary molars is therefore, of prim importance for a longer lasting tooth. The aim of this article was to look at the potential improvement and longevity of 2nd primary molar root canal therapy using Gutta percha when missing successors. A 9 year old male patient was attended to the Department of Pedodontics, Shahid Beheshti University, for routine check up. There was no report of any medical problem in his history. Radiographic investigation of the case using an OPG revealed the missing of both lower 5�s. This was while both mandibular 2nd primary molars were carious involving pulp. All carious tissues were removed followed by an opening into the pulp chamber under local anesthesia and rubber dam isolation. The inflamed and hyperemic pulp was removed as routine, irrigated, dried ready for root filling. All three root canals were then dressed temporarily using a cotton pellet placed in to the pulp chamber covered with reinforced ZOE. Each root of the treating teeth was then obturated in the second visit using Gutta-percha and ZOE sealer through the lateral condensation technique. Radiographs were obtained before, immediately after and in 6 month follow up to assess the periapical as well as forcation of the teeth. Second primary molars with missing successors tend to stay intact in a longer period when treated with Gutta Perchae root filling compare to Pure ZOE paste as they would not resorbe quickly.