Authors : V.O.J. Fuentes , P. Fuentes-Castro , M. Fuentes-Castro , A. Bernal-Canseco , R. Orozco-Hernandez and J.J. Uribe-Gomez
Abstract: With the objective of studying the pattern of LH secretion in the anoestrus goat and the pharmacological effect of a subcutaneous implant containing 15 mg naloxone on the plasmatic concentrations of LH in the goat during the anoestrus period. 15 Alpine does were selected, body weight and age averaged 35.8 kg and 8 months respectively all goats chosen were considered sexually mature. The experiment was carried out during the months of May and June 2005 during seasonal anestrus in this latitude (19 13�North). In groups of five chosen at random, they were allocated as follows: Group A was used as control injected i.m. with 2 mL saline at 12 h intervals for 15 days, group B received a subcutaneous implant of 15 mg naloxone. And group C received an i.m. injection of 0.5 mg naloxone i.m. at 12 h intervals (8:00 and 20:00 h) for 15 days. In all groups LH values were similar to those observed in day 0, 5 and 10 no difference was detected between groups but treated groups showed signicant surges of LH. On the 15th day of treatment a significant difference was observed between treated animals (implant and injection), significant surges of LH were observed in treated groups; On day 20 implanted animals showed higher levels of LH than injected and control groups with a significant surge detected during the sampling period. In control goats basal LH levels were maintained during the period of study. It was concluded that the administration of naloxone by implant induced LH increases significantly greater as compared with the injection group and that the concentration of LH in control groups it was similar to the one reported in sheep.
V.O.J. Fuentes , P. Fuentes-Castro , M. Fuentes-Castro , A. Bernal-Canseco , R. Orozco-Hernandez and J.J. Uribe-Gomez , 2007. The Pharmacological Effect of Small Doses of an Engogenous Opioid Antagonist on the Pulsatile Secretion of LH in the Goat During Anoestrus. Research Journal of Pharmacology, 1: 14-18.