Authors : Murugan Rajadurai , Mannangatti Padmanabhan and Ponnaian Stanely Mainzen Prince
Abstract: The present study investigates the effect of oral administration of an aqueous Aegle marmelos leaf extract (AMLEt) on lipid peroxidation and antioxidants in isoproterenol (ISO) treated rats. A significant increase in the activities of marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate transaminase and alanine transminase in serum of isoproterenol treated rats was observed. The levels of thiobarbituric acid reactive substances and hydroperoxides increased but the levels and activities of nonenzymic (vitamin C, reduced glutathione and ceruloplasmin) and enzymic (glutathione peroxidase, superoxide dismutase and catalase) antioxidants decreased in isoproterenol administered rats. Pretreatment with aqueous AMLEt at doses of 100 and 200 mg/kg orally for a period of 35 days exerted a significant effect on isoproterenol treated rats. The effect of AMLEt at a dose of 200 mg/kg showed a similar effect as that of ?-tocopherol (60 mg/kg). Thus the results of our study show the cardioprotective activity of Aegle marmelos leaf extract in isoproterenol induced myocardial infarction in rats.
Murugan Rajadurai , Mannangatti Padmanabhan and Ponnaian Stanely Mainzen Prince , 2005. Effect of Aegle marmelos Leaf Extract and -Tocopherol on Lipid Peroxidation and Antioxidants in Isoproterenol Induced Myocardial Infarction in Rats . The Cardiology, 1: 40-45.