Authors : S.B. Oladele , P. Abdu , A.J. Nok , N.D.G. Ibrahim and K.A.N. Esievo
Abstract: Twenty-five Shaver Brown chickens were inoculated intramuscularly at 4 weeks with Newcastle Disease Virus (NDV) Kudu 113 strain. Another 25 chickens served as controls. Values of neuramindase activity (NA), free serum sialic acid (FSSA), erythocytes surface sialic acid (ESSA), packed cell volume (PCV) and haemagglutination inhibition (HI) antibody titres to NDV were determined for each chicken. The infected chickens had clinical signs due to newcastle disease (ND) by day three post-infection (pi). Mortality and morbidity were 52 and 100%, respectively. The major gross lesions observed in the infected chickens were haemorrhages in the proventricular mucosa, the caecal tonsils and the mucosal layer of the intestine. There was a significant decrease in daily mean values of PCV from days 3-7 pi in the infected chickens. This period coincided with the time of elevated values of HI anitibody titre, NA, FSSA and a decrease in ESSA.
S.B. Oladele , P. Abdu , A.J. Nok , N.D.G. Ibrahim and K.A.N. Esievo , 2008. Pathogenesis of Newcastle Disease Virus Kudu 113 Strain in Relation to Neuraminidase Production in Chickens. Veterinary Research, 2: 3-8.