Abstract: An experiment was conducted to determine the antitrypanosomal activities of natural honey on wistar rats infected with Trypanosoma congolense. Twenty four albino rats (males and females) of wistar strain weighing about 90-110 g were used the animals were housed in well ventilated cages and kept under controlled environmental conditions. Each rat was inoculated intraperitoneally with 1.0x10⁵ mL^-1 of the T. congolense. The rats were divided into 3 groups A-C with 8 rats per group. Group A that served as the control were infected and given distilled water, group B and C were infected and treated with diminazine aceturate and natural honey, respectively at 7th day post infection. The parasitaemia levels, mean body weight changes and haematological parameters were analysed using one way ANOVA. The parasitaemia levels, mean body weight and haematological parameters were significantly different (p<0.05) in the three groups. There was a total clearance in the parasitemia level of the group B treated with diminazene aceturate while in group C there was reduction but no total clearance. It was concluded that natural honey even as part of regular diet could be a useful, cheap and readily available agent in the management of African trypanosomosis in an endemic area.