Journal of Animal and Veterinary Advances

Year: 2012
Volume: 11
Issue: 12
Page No. 2013 - 2019

Hypolipidemic and Hypocholestrolemic Effect of Medicinal Plant Combination in the Diet of Rats: Black Cumin Seed (Nigella sativa) and Turmeric (Curcumin)

Authors : M.H. Al-Nazawi and S.M. El-Bahr

References

AOAC., 1995. Official Methods of Analysis. 16th Edn., Association of Official Analytical Chemists, Washington, DC., USA.

Abd El-Aal, E.S.M. and R.S. Attia, 1993. Characterization of black cumin (Nigella sativa): Chemical composition and lipid. Alexandria Sci. Exchange, 14: 467-482.

Abu-Al-Basal, M.A., 2011. Influence of Nigella sativa fixed oil on some blood parameters and histopathology of skin in staphylococcal-infected BALB/c mice. Pak. J. Biol. Sci., 14: 1038-1046.
CrossRef  |  

Agarwal, P., M.D. Kharya and R. Shrivastava, 1979. Antimicrobial and anthelmintic activities of the essential oil of Nigella sativa L. Ind. J. Exp. Biol., 17: 1264-1275.
PubMed  |  

Aggarwal, B.B., A. Kumar, M.S. Aggarwal and S. Shishodia, 2005. Curcumin Derived From Turmeric (Curcuma longa): A Spice for all Seasons. In: Phytopharmaceuticals in Cancer Chemoprevention, Preuss, H.G. (Eds). CRC Press Inc., Boca Raton, USA, pp: 349-387.

Akhtar, M.S., Z. Nasir and A.R. Abid, 2003. Effect of feeding powdered Nigella sativa L. seeds on poultry egg production and their suitability for human consumption. Veterinarski Arhiv., 73: 181-190.
Direct Link  |  

Alsaif, M.A., 2008. Effect of Nigella sativa oil on metabolic responses to prolonged systemic injury in rats. J. Boil. Sci., 8: 974-983.
CrossRef  |  Direct Link  |  

Badari, O.A., A.B. Abdel-Naim, M.H. Abdel-Wahab and F.M. Hamada, 2000. The influence of thymoquinon on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology, 143: 219-226.
PubMed  |  

Bamosa, A.O., B.A. Ali and S.A. Sowayan, 1997. Effect of oral ingestion of Nigella sativa seeds on some blood parameters. Saudi Pharm. J., 5: 126-129.
Direct Link  |  

Basavaraj, M., V. Nagabhushana, N. Prakash, M.M. Appannavar, P. Wagmare and S. Mallikarjunappa, 2011. Effect of dietary supplementation of Curcuma longa on the biochemical profile and meat characteristics of broiler rabbits under summer stress. Vet. World, 4: 15-18.
CrossRef  |  Direct Link  |  

Bashandy, S.A.E., 1996. Effect of Nigella sativa oil on liver and kidney functions of adult and senile rats. Egypt. J. Pharm. Sci., 37: 313-327.

Bauer, J.D., 1982. Clinical Laboratory Methods. 9th Edn., The C.V. Company II 1830, Westline Industrial, Missouri.

Buriro, M.A. and M. Tayyab, 2007. Effect of Nigella sativa on lipid profile in albino rats. Gomal J. Med. Sci., 5: 28-31.
Direct Link  |  

Chaudary, S.A., 1996. Serum lipid profile in albino rats fed on atherogenic supplemented palm oil diet and Nigella sativa. Ph.D. Thesis, Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan.

Chou Y.H., 1975. Experimental Design and the Analysis of Variance, Statistical Analysis-I. Holt, Reinhart and Winston Publication, New York, pp: 340-352.

Dehkordi, F.R. and A.F. Kamkhah, 2008. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam. Clin. Pharmacol., 22: 447-452.
PubMed  |  

Doumas, B.T., D.D. Bayson, R.J. Carter, T. Peters and R. Schaffer, 1981. Estimation of total serum protein. Clin. Chem., 27: 1642-1643.

Ekanem, J.T. and O.K. Yusuf, 2008. Some biochemical and haematological effects of black seed (Nigella sativa) oil on T. brucei-infected rats. Afr. J. Biomed. Res., 11: 79-85.
Direct Link  |  

El-Bagir, N.M., I.T.O. Farah, A. Alhaidary, H.E. Mohamed and A.C. Beynen, 2010. Clinical laboratory serum values in rabbits fed diets containing black cumin seed. J. Anim. Vet. Adv., 9: 2532-2536.
CrossRef  |  Direct Link  |  

El-Bahr, S.M. and T.T. Saad, 2008. Effect of black cumin seeds (Nigella sativa) and/or Turmeric (Curcumin) on hematological, biochemical and immunological parameters of Mugil cephalus fish vaccinated with Aeromonus hydrophila bacterin. Proceedings of the 13th Scientific Congress, November 25-28, 2008, Faculty of Veterinary Medicine, Assuit University, pp: 365-388.

El-Bahr, S.M., 2007. Effect of black cumin seeds (Nigella sativa) on the profile of serum lipids, lipoproteins and fatty acids in pekin ducklings. Int. J. Applied Chem., 3: 221-230.
Direct Link  |  

El-Bahr, S.M., M.A. Korshom, A.E.A. Mandour, A.A. El-Bessomy and M.A. Lebdah, 2007. The protective effect of Turmeric on iron overload in albino rats. Egypt. J. Biochem. Mol. Biol., 25: 94-113.
Direct Link  |  

El-Beshbishy, H.A., AN.B. Singab, J. Sinkkonen and L. Pihlaja, 2006. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementations in cholesterol fed rats. Life Sci., 78: 2724-2733.
Direct Link  |  

El-Dakhakhny, M., N.I. Mady and M.A. Halim, 2000. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung, 50: 832-836.
CrossRef  |  PubMed  |  Direct Link  |  

Emadi, M., H. Kermanshahi and E. Maroufyan, 2007. Effect of varying levels of turmeric rhizome powder on some blood parameters of broiler chickens fed corn-soybean meal based diets. Int. J. Poult. Sci., 6: 345-348.
CrossRef  |  Direct Link  |  

Genest, J.J., M. Marcil, M. Denis and L. Yu, 1999. High density lipoproteins in health and in disease. J. Investig. Med., 47: 31-42.
PubMed  |  

Gilani, A.H., Q. Jabeen and M.A.U. Khan, 2004. A review of medicinal uses and pharmacological activities of Nigella sativa. Pak. J. Biol. Sci., 7: 441-451.
CrossRef  |  Direct Link  |  

Gottfried, S.P. and B. Rosenberg, 1973. Improved manual spectrophotometric procedure for determination of serum triglycerides. Clin. Chem., 19: 1077-1078.
Direct Link  |  

Hasan, M.M., S.P. Chowdhury, Shahidul Alam, B. Hossain and M.S. Alam, 2005. Antifungal effects of plant extracts on seed-borne fungi of wheat seed regarding seed germination, Seedling health and vigour index. Pak. J. Biol. Sci., 8: 1284-1289.
CrossRef  |  Direct Link  |  

Hassanin, N.I. and F.M. Hassan, 1996. A preliminary study on the effect of Nigella sativa L. seeds on hypoglycemia. Vet. Med. J. Giza, 44: 699-708.
Direct Link  |  

Hedaya, S.A., 1995. Effect of Nigella sativa (black seeds) extract on some haematological and biochemical parameters in rats. Alex. J. Vet. Sci., 11: 95-99.

Hussain, H.E.M.A., 2002. Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn and partially purified product from Abroma augusta, Linn. in streptozotocin induced diabetes. Indian J. Clin. Biochem., 17: 33-43.
CrossRef  |  Direct Link  |  

Ibraheim, Z.Z., 2002. Effect of Nigella sativa seeds and total oil on some blood parameters in female doxorubicin volunteers. Saudi Pharm. J., 10: 54-59.

Jaffar, A.R., J. Babb and A. Movahed, 2004. Optimal management of hyperlipidemia in primary prevention of cardiovascular disease. Int. J. Cardiol., 97: 355-366.
PubMed  |  

Kim, M. and Y. Kim, 2010. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr. Res. Pract., 4: 191-195.
CrossRef  |  Direct Link  |  

Kocyigit, Y., Y. Atamer and E. Uysal, 2009. The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. Saudi Med. J., 30: 893-896.
PubMed  |  Direct Link  |  

Liu, T.Z., 1979. Simplified enzymic/colorimetric serum urea nitrogen determination. Clin. Chem., 25: 336-337.
CrossRef  |  PubMed  |  Direct Link  |  

Mahfouz, M., M. El-Dakhakhny, A. Gemel and H. Moussa, 1962. Choleretic action of Nigella sativa seed oil. Egypt. Pharm. Bull., 44: 225-229.

Mehta, A., G. Kaur and M. Chintamaneni, 2012. Piperine and quercetin enhances antioxidant and hepatoprotective effect of curcumin in paracetamol induced oxidative stress. Int. J. Pharmacol., 8: 101-107.
CrossRef  |  Direct Link  |  

Nader, M.A., D.S. El-Agamy and G.M. Suddek, 2010. Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch. Pharm. Res., 33: 637-643.
PubMed  |  Direct Link  |  

Nasir, Z. and M.A. Grashorn, 2010. Effects of Echinacea purpurea and Nigella sativa supplementation on broiler performance, carcass and meat quality. J. Anim. Feed Sci., 19: 94-104.
Direct Link  |  

Nouzarian, R., S.A. Tabeidian, M. Toghyani, G. Ghalamkari and M. Toghyani, 2011. Effect of turmeric powder on performance, carcass traits, humoral immune responses, and serum metabolites in broiler chickens. J. Anim. Feed Sci., 20: 389-400.
Direct Link  |  

Pal, S., T. Choudhuri, S. Chattopadhyay, A., Bhattacharya, G.K. Datta, T. Das and G. Sa, 2001. Mechanisms of curcumin induced apoptosis of Ehrlich`s ascites carcinoma cells. Biochem. Biophys. Res. Commun., 288: 658-665.
PubMed  |  

Pourghassem-Gargari, B., V. Ebrahimzadeh-Attary, M. Rafraf and A. Gorbani, 2009. Effect of dietary supplementation with Nigella sativa L. on serum lipid profile, lipid peroxidation and antioxidant defense system in hyperlipidemic rabbits. J. Med. Plants Res., 3: 815-821.
Direct Link  |  

Rathee, P.S., S.H. Mishra and R. Kaushal, 1982. Antimicrobial activity of essential oil, fixed oil and unsaponifiable matter of Nigella sativa L. Indian J. Pharm. Sci., 44: 8-10.

Reddy, A.C.P. and B.R. Lokesh, 1994. Alterations in lipid peroxides in rat liver by dietary n-3 fatty acids: Modulation of antioxidant enzymes by curcumin, eugenol and vitamin E. J. Nutr. Biochem., 5: 181-188.
CrossRef  |  Direct Link  |  

Reinhold, R.R., 1953. Determination of serum albumin. Clin. Chem., 21: 1370-1372.

Reitman, S. and S. Frankel, 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28: 56-63.
CrossRef  |  PubMed  |  Direct Link  |  

Salama, A.F. and S.M. El-Bahr, 2007. Effect of curcumin on cadmium-induced oxidative testicular damage in rats. J. Med. Res. Inst., 28: 167-173.

Shewita, R.S. and A.E. Taha, 2011. Effect of dietary supplementation of different levels of black seed (Nigella sativa L.) on growth performance, immunological, hematological and carcass parameters of broiler chicks. World Acad. Sci. Eng. Technol., 5: 304-310.
Direct Link  |  

Sivabalan, S. and C.V. Anuradha, 2010. A comparative study on the antioxidant and glucose-lowering effects of curcumin and bisdemethoxycurcumin analog through in vitro assays. Int. J. Pharmacol., 6: 664-669.
CrossRef  |  Direct Link  |  

Soliman, G.Z.A., 2005. Effect of curcumin, mixture of curcumin and piperine and curcum (Turmeric) on lipid profile of normal and hyperlipidemic rats. Egypt. J. Hosp. Med., 21: 145-161.
Direct Link  |  

Srinivasan, K., 2005. Role of spices beyond food flavoring: Nutraceuticals with multiple health effects. Food Rev. Int., 21: 167-188.
CrossRef  |  Direct Link  |  

Sugiharto, I., E. Widiastuti and N.S. Prabowo, 2011. Effect of turmeric on blood parameters, feed efficiency and abdominal fat content in broilers. J. Indonesian Trop. Anim. Agric., 36: 21-26.

Tasawar, Z., Z. Siraj, N. Ahmad and M.H. Lashari, 2011. The effects of Nigella sativa (Kalonji) on lipid profile in patients with stable coronary artery disease in multan, Pakistan. Pak. J. Nutr., 10: 162-167.
CrossRef  |  Direct Link  |  

Tayyab, M., 1995. Effect of consumption of dietary elaesis guineensis (Palm kernel) seeds on serum lipid profile in albino rats. Ph.D. Thesis, Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan.

Tousson, E., M., El-moghazy and E. El-Atrsh, 2011. The possible effect of diets containing Nigella sativa and Thymus vulgaris on blood parameters and some organs structure in rabbit. Toxicol. Ind. Health, 27: 107-116.
PubMed  |  

Weggemans, R.M. and E.A. Trautwein, 2003. Relation between soyassociated isoflavones and LDL and HDL cholesterol concentrations in humans: A meta analyses. Eur. J. Clin. Nutr., 57: 940-946.
PubMed  |  

Zak, B., R.C. Dickenman, E.G. White, H. Burnett and P.J. Cherney, 1954. Rapid estimation of free and total cholesterol. Am. J. Clin. Pathol., 24: 1307-1315.
CrossRef  |  PubMed  |  Direct Link  |  

Zaoui, A., Y. Cherrah, K. Aloui, N. Mahassine, H. Amarouch and M. Hassar, 2002. Effect of Nigella sativa fixed oil on blood homeostasis in rat. J. Ethnopharmacol., 79: 23-26.
CrossRef  |  Direct Link  |  

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