Authors : O.A. Olowe and B.W. Aboderin
Abstract: ESBL producers have continued to draw increasing attention globally with their attendant problems of clinical failure to new generation antibiotics and nosocomial spread. In Nigeria, several reports have indicated the presence and severity of ESBL producers. In this study, researchers demonstrate the presence of ESBL strains of E. coli and Klebsiella sp. from the clinical samples in a tertiary medical institution in Abeokuta, Ogun State, Nigeria. About 160 clinical isolates samples were analyzed and cultured at the micro unit. Isolates of E. coli and Klebsiella were screened for ESBL producers by double disk synergy test on Mueller Hinton Agar. Susceptibility to some common antibiotics were also tested by disk diffusion method. About 80 isolates were recovered, 14 (17.5%), Klebsiella pneumoniae, 22 (27.5%), Klebsillea oxytoca and 44 (55%). E. coli ESBl producers was 75% Klebsiella pneumoniae 5%; Escheirchia coli 2.5%. Age group 1-10 gave highest percentage of isolate (66.7%) and age group 41-50 the lowest (15%). Sputum and wound swab were the only sample sites that yielded ESBL producers. The presence of ESBL producers has now been established in Abeokuta, concerted effort should be made toward initiating an early detection system for ESBL producing isolates in our hospitalized patients. In addition, appropriate control measures should be put in place to prevent nosocomial spread of infection.
O.A. Olowe and B.W. Aboderin, 2010. Detection of Extended Spectrum β-Lactamase Producing Strains of (Escherichia coli) and (Klebsiella sp.) in a Tertiary Health Centre in Ogun State. International Journal of Tropical Medicine, 5: 62-64.