Abstract: Burn is one of the most expensive damages that could be happened at any age. Furthermore, extensive burns can lead to death. Over 90% of deaths caused by burns happen in poor countries where preventive programs are less common and the quality of burn management is low. Although most death cases are because of burn shocks and infections, the methods of treating burn patients particularly rehydration method and administration of topical or systemic antibiotics are still faced with serious challenges. The present systematic review was carried out in order to increase awareness and propose appropriate methods to treatment and manage of patient’s burn, by searching the databases of PubMed/Medline, Web of Science, Scopus and the Google Scholar using appropriate keywords. In the beginning of the study, 124 Articles were obtained from the electronic search, from among which 63 relevant articles were chosen. Out of those 63, Article, 21 ones were in line with the objective of the present study. Since the breadth and depth of burns play an important role in the rate of the patients’ morbidity and mortality and determination of their precaution, the method of calculating them in children and adults and the relevant protocols in dealing with burns were examined and presented. Determining appropriate protocol can differ according to the patient’s conditions and it is suggested that clinical trials should be carried out on this issue.