Authors : Lida Haghnazari, Hamid Nomani, Hamed Nowroozi, Osman Hesami, Mehrali Rahimi and Sahar Foroughinia
Abstract: Adiponectin decreases in Type 2 diabetes mellitus, insulin resistance and obesity. However, increases in several chronic statuses such as Type I diabetes associated with nephropathy or cardiovascular diseases. In this study, we investigated whether serum level of adiponectin may be considered as a useful biochemical marker for differentiating T1DM and T2DM and correlation with lipid profiles, waist circumstance and body mass index in Kermanshah population, West of Iran. This cross-sectional study was conducted on 100 diabetic patients Type 2 and 89 diabetic Type I and 99 and 66 non diabetic as control group matched for age and sex with T2DM and T1DM, respectively. Levels of adiponectin, HbA1c, lipid profiles were measured by ELISA, glycated hemoglobin and enzyme assay, respectively. Our finding showed, levels of serum adiponectin significantly increased in T1DM patients and decreased in T2DM patients. In addition, serum adiponectin concentration in T1DM patients was significantly higher of T2DM . Serum adiponectin level was significantly positive correlation with HbA1c in T1DM and with HDL-C in T2DM. Lipid profiles except of HDL-C were significantly higher in T2DM patients compared with T1DM patients. There was a significantly negative correlation between serum levels of adiponectin and obesity in T1DM and T2DM. Hypoadiponectinemia associated with obesity and T2DM patients while closed with T1DM and decrease BMI and serum adiponectin concentration which may be considered as a useful biochemical marker for differentiating T1DM and T2DM.
Lida Haghnazari, Hamid Nomani, Hamed Nowroozi, Osman Hesami, Mehrali Rahimi and Sahar Foroughinia, 2016. Hypoadiponectinemia Associated in Obesity and Type 2 Diabetes and Hyperadiponectinemia Closed with Type I Diabetes. International Journal of Tropical Medicine, 11: 165-169.