Authors : Seyed Masood Seyedian, Farzaneh Ahmadi, Parvin Ghorbani, Seyed Mohammah Hassan Adeland and Seyed Mohammah Hassan Aletayeb
Abstract: Glucose-6-phosphatase dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans, affecting 400 million people worldwide. It is inherited as an X-recessive linked disorder. Evidence indicates that G6PD-deficient patients are protected against cardiovascular disease. Thus we decided to test this hypothesis in male subjects expressing the G6PD deficiency phenotyp. We evaluated 420 man patients with CoronaryAartery Disease (CAD) admitted for angiography in Ahvaz Golestan Hospital. The G6PD phenotype was determined using fluorescent spot test method. Twenty-eight out of 420 (6.7%) patients were G6PD deficient. In addition, the frequency of dyslipidemia in patients with G6PD deficiency was lower than patients with normal enzyme activity (p<0.05). Our findings confirmed the hypothesis that susceptibility to CAD in G6PD-deficient patients is less. We suggest that protective efect may reduce LDL and total cholesterol level by inhibiting of cholesterol biosynthesis.
Seyed Masood Seyedian, Farzaneh Ahmadi, Parvin Ghorbani, Seyed Mohammah Hassan Adeland and Seyed Mohammah Hassan Aletayeb, 2016. Glucose-6-Phosphate Dehydrogenase Deficiency and Coronary Artery Disease. International Journal of Tropical Medicine, 11: 186-188.