Abstract: Cardiovascular disease which one of its causes is hypertension is the major cause of death globally in which there are more people died because of cardiovascular disease than other causes. In Indonesia, based on Basic Health Research data for blood pressure measurement and direct interview to those aged older than 18 year, the highest prevalence of hypertension for Sumatera region was found in Bangka Belitung (30.9%), then followed by South Sumatera (26.1%). This study aimed to determine relation between consumption of salted fish containing high level of Natrium Chloride (NaCl) and hypertension incidence. This study used cross-sectional design and involved 90 persons as sample. Analysis used was univariate, bivariate and multivariate with logistic regression method. Results of study showed that respondents who consumed salted fish containing high level of NaCl were more likely to suffer from hypertension 2.024 times (95% CI 0.727 5.633) than respondents who consumed salted fish containing low level of NaCl after controlling or equalizing condition of consumption of fatty food, physical activities, body mass index and age. For respondent’s age category, the older the age of respondents, they were more likely to suffer from hypertension 6.83 times (95% CI 2.279-20.469). In variable body mass index, it was concluded that respondents whose body mass index exceeding the normal limit (>24) were more likely to suffer from hypertension 1.863 times (95% CI 1.123-9.989). Meanwhile, in variable fatty food, respondents who consumed fatty food were found more likely to suffer from hypertension 0.312 times (95% CI 0.185-1.676). Based on results of study, any promoting and educational actions should be performed concerning on nutrition of high salty food, especially salted fish and fatty food that may cause hypertension. Then it needs any cooperation with cross sectors closed to communities such as Family Welfare Movement (PKK), religious organizations, health workers, etc for early detection as well as counseling of hypertension and any other particular non-infectious diseases. Palembang City Health Agency should cooperate with Palembang City Food and Drug Monitoring Agency (BPOM) to conduct socialization to salted fish sellers about the way of producing salted fish based on SNI standards.