Authors : Saman Hosseini and Mir Behrad Khamesee
Abstract: The impact of H. pylori eradication on the platelet count in patients with Immune Thrombocytopenic Purpura is controversial. In this clinical trial, the effects of HP eradication on platelet count was assessed and analyzed. Forty Iranian patients with ITP were assessed in two groups. One group was treated with amoxicillin, clarithromycin and omeprazole. The other group received similar amounts of placebo. The platelet counts were analyzed before treatment and during the first, second and third months after treatment. The mean platelet count before treatment in the intervention and control groups were, 67.85×103 and 69.4×103 mm3, respectively (p = 0.82). In the third month after treatment, it was 107.15×103 mm3 in the intervention group and the 71.15×103 mm3 in the control group (p<0.001). Repeated measures analysis confirmed the positive effect of H. pylori eradication on platelet count (p = 0.007). In this study, it was found that H. pylori eradication in patients with immune thrombocytopenic purpura induced a dramatic increase in platelets count.
Saman Hosseini and Mir Behrad Khamesee, 2022. Assessment of Helicobacter pylori Eradication Treatment on Platelet Count in Patients with Immune Thrombocytopenic Purpura. International Journal of Tropical Medicine, 17: 20-28.