Authors : A.B.Z. Zuki , D. Saudi , A. Jalila , R. Mustaffa and Y. Norimah
Abstract: The present study was conducted to evaluate the potential of cockle (Anadara granosa) shell as an alternative biomaterial for bone substitute. The cockle shells were cleaned thoroughly and dried in oven (50 C) for 3 days. The shells were then ground by using Blendor (240V) and sieved twice at 850 m and followed by 420 m. The powder was compressed to form dense pellet by using uniaxial compress technique. Three adult New Zealand White rabbits were used in this study. Each rabbit was implanted with cockle shell, cockle shell+binder and cockle shell+Hydroxiappatite (HA). The right and left gluteal muscles was implanted with cockle shell+binder and cockle shell+HA respectively, while the semitendinosus muscle was implanted with cockle shell. Radiography and ultrasonography techniques were used to evaluate the implant materials post-implantation. The animals were euthanased at three weeks post-implantation and samples of the implant materials and surrounding tissues were taken for histological evaluation. Result of the study revealed that after three weeks post-implantation, no new bone formation was detected. However, the ultrasound and the radiographic evaluations revealed the absorption and tissue reaction at the implantation sites.
A.B.Z. Zuki , D. Saudi , A. Jalila , R. Mustaffa and Y. Norimah , 2004. Evaluation of Anadara granosa Shell Post Muscle Implantation in Animal Model: A Preliminary Study . Journal of Animal and Veterinary Advances, 3: 571-574.