Authors : R. Manoj Kumar , A. Sanyal and D. Hemadri
Abstract: In the present work, the effect of antibodies (raised in Bovine against IND 63/72 and in Guineapigs against IND 63/72 and IND 491/97) on foot-and-mouth disease serotype Asia1 vaccine strain IND 63/72 was compared by analyzing the data obtained in nucleotide sequencing. The Nr viruses (neutralization resistant viruses) which were selected by growing them in the presence of antibodies (Bovine Vaccinate Serum, BVS and Guineapig Serum, GPS) showed certain characteristic features like common changes in the structural protein coding P1 region of this virus. This shows that the virus responds equally to the antibodies raised in both bovine (natural host) and guineapig (experimental host). The result hereIn extends the finding that selection exerted by host antibody also plays a major role in the rapid evolution of FMD Virus serotype Asia1.
R. Manoj Kumar , A. Sanyal and D. Hemadri , 2006. Effect of Antibodies Raised in Bovine and Guineapigs on The Genetic Characters of Seroytpe Asia1 FMD Virus. Journal of Animal and Veterinary Advances, 5: 294-297.