Abstract: This study was intended to evaluate the anesthetic quality produced by the Propofol (P) (2 mg kg ¹, I.V) and Thiopental (T) (10 mg kg ¹, I.V) in 6 donkeys premedicated with Xylazine (X) (1 mg kg ¹, I.V). Each d onkey was anesthetized 1 time with each dose of P and T, 5 min after X administration in random order at 1 week intervals. Data were collected continuously before premedication and after anesthetic induction at 10, 20 and 30 min (induction time, sleeping time, abolishment of the swallowing reflex period, recumbency period, heart rate and respiratory rate). Quality of induction, recovery, mouth opening, intubation and number of attempts requiring the donkeys to regain the sternal recumbency and standing position were qualitatively and quantitatively assessed. The results revealed the presence of a mild range of differences in the quality of anesthesia between P and T. A significant difference at the level of (p<0.05) was detected between P and T protocols; induction time (40.50�9.36 sec) and (18.50�9.14 sec), sleeping time (12.5�2.1 min) and (30.5�5.42 min) and in the abolishment of swallowing reflex (9.5�1.55 min) and (20.25�3.47 min), respectively. On the other hand, the quality of induction with T provided a smooth and uneventful induction of anesthesia and was greatest in quality than P and animals anesthetized with T required the maximum number of attempts to reach sternal recumbency than P, at p<0.05. Clinically, anesthesia by T produced longer narcosis and abolishment of swallowing reflex, rapid induction time, long recumbency period than P. Anesthesia with T produced good and excellent anesthetic protocol for induction of general anesthesia in donkeys when compared with anesthesia by P.