Authors : S. Varzandian , M.M. Mokhtari , M. Moosavi and A.A. Mahjoor
Abstract: Contrast studies have long been considered essential procedures for evaluating diseases of the gastrointestinal tract. While it is generally accepted that these procedures are safe and morbidity is low, unfortunately such procedures are not entirely innocuous and serious complications have been reported. Thirty male New Zealand white rabbits aged about 6 mounts with average body weight of 2500�400 g were selected for this study. Rabbits were divided randomly into 6 equal groups (n = 5). Rabbits in groups 1 and 2 were injected barium sulfate 30% intraperitoneally. The 3rd and 4th groups were injected garstrografin at the same way. Animals in 5th and 6th group (control) were injected physiologic saline solution as well. Radiographs were provided of all animals at 20 min, 24 h and 7 days after injection. Animals in groups 1, 3 and 5 were sacrificed on 24 h and group 2, 4 and 6 were sacrificed on 7th day after injection. Histopathological changes of group 1 samples indicated; increasing of mononuclear inflammatory cells, fibrocytes and fibrin on the peritoneal membrane showed severe peritonitis. In group 2 inflammatory cells were decrease and they converted to polymorphs. There are no significant histhipathologic changes in groups 3-6. Radiographic finding also showed that barium sulfate remained in the abdominal cavity and lead to produces ascitis, while gastrografin nearly have any side effects on animals.
S. Varzandian , M.M. Mokhtari , M. Moosavi and A.A. Mahjoor , 2008. Comparative Study of Histopathologic Effects of Barium Sulfate and Gastrografin on Peritoneal Membrane in Rabbits. Journal of Animal and Veterinary Advances, 7: 445-447.