Authors : Kazuhito Itamoto, Munekazu Nakaichi, Masaru Okuda, Takeshige Otoi, Hisashi Inokuma and Yasuho Taura
Abstract: The effects of Medetomidine (Me) and Atipamezole (Ati) on Intracranial Pressure (ICP) and Cerebral Perfusion Pressure (CPP) were studied in 12 dogs with artificial intracranial space-occupied lesions. The dogs were randomly assigned to a Me-Physiological Saline (PSS) group (n = 6) or a Me-Ati group (n = 6). All dogs were anesthetized with oxygen-isoflurane inhalation anesthesia and received an intramuscular injection of Me (80 μg kg-1) as an initial treatment. At 30 min after administration of Me, the dogs in the Me-PSS and Me-Ati groups received an intramuscular injection of PSS or Ati (400 μg kg-1) as a second treatment, respectively. Me produced a significant decrease of ICP in both groups. The administration of Ati produced a transient decrease in CPP associated with a decrease in arterial blood pressure. The lowest value of CPP (27.8 mmHg) was recorded at 10 min after administration of Ati. These results suggest that adequate cerebral blood flow is temporarily inhibited by Ati administration. Therefore, we conclude that Ati should be used with caution in patients with intracranial lesions.
Kazuhito Itamoto, Munekazu Nakaichi, Masaru Okuda, Takeshige Otoi, Hisashi Inokuma and Yasuho Taura, 2010. Effects of Medetomidine and Atipamezole on Cerebral Perfusion Pressure in Dogs. Journal of Animal and Veterinary Advances, 9: 913-919.