Authors : Pin Chen, Yingyu Liu , Yang Wang , Wentao Li , Dingren Bi and Qigai He
Abstract: Streptomycin and sulfonamide resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. The aim of the present research was to determine the molecular mechanism of Haemophilus parasuis resistant to streptomycin and sulfonamide. One high level streptomycin and sulfonamide-resistant isolate from China was submitted for MIC determination and plasmid extract, then sequencing and annotation. One plasmid extracted from the bacteria strain, designated pHPS-A67 (4.2 kb), contain fifteen open reading frames including streptomycin resistance gene StrA, sulfonamide resistance gene Sul 2 and mobilization protein genes Mob A, Mob B and Mob C. This is believed to be the first report of native Haemophilus parasuis contains plasmid which mediated streptomycin and sulfonamide resistance in this microorganism.
Pin Chen, Yingyu Liu , Yang Wang , Wentao Li , Dingren Bi and Qigai He , 2012. Plasmid Mediated Streptomycin and Sulfonamide Resistance in Haemophilus parasuis . Journal of Animal and Veterinary Advances, 11: 1106-1109.