Authors : Takeshi Ohta, Masami Shinohara, Takuji Yamamoto and Takahisa Yamada
Abstract: The Spontaneously Diabetic Torii (SDT) rat is a non-obese diabetic model showing various metabolic abnormalities in pre-diabetic stage. In this study, researchers investigated the pancreatic function at young ages, 5 and 7 weeks. At 5 weeks, SDT rats showed glucose intolerance and reduction of Homeostasis Model Assessment (HOMA)-β. At 7 weeks, the insulin content in pancreas was also decreased. Insulinogenic index showed no change at 5 and 7 weeks of age. In conclusion, the pancreatic function in SDT rats was decreased from a young age after weaning and the rat is a useful Animal Model to examine the pathophysiological features of Impaired Glucose Tolerance (IGT).
Takeshi Ohta, Masami Shinohara, Takuji Yamamoto and Takahisa Yamada , 2012. Pancreatic Abnormalities at a Young Age in Spontaneously Diabetic Torii (SDT) Rats. Journal of Animal and Veterinary Advances, 11: 1322-1326.